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For example, recent meta-analyses of the association between schizophrenia and urbanicity and migrant status revealed a pooled odds ratio of 2. 39 for urbanicity (Vassos et al. A single mutation in a candidate gene is unlikely to have a big impact in the population, by taking the aggregate effect of all mutations; however, we can differentiate people being at high genetic risk for disease. A polygenic architecture for psychiatric disorders of many weakly contributing variants means that genetic effects interact on the scale of disease (i.affected v.