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We advocate its use in patients with complicated CDI if there is no immediate indication for operative intervention. There are no RCTs available to guide recommendations for the choice and dosing of antibiotic therapy for the treatment of patients with severe CDI. Recommendations are extrapolated from clinical experience and data pertaining to RCDI, as well as consideration of impaired gastrointestinal motility and ileus that occurs in these patients (32).

Fidaxomicin, as mentioned previously, was not inferior to best trading platform for uk for initial cure for CDI, but no data are available on the efficacy of this drug in severe or complicated disease. Tigecycline is a novel analog of minocycline that exhibits broad antimicrobial activity against Gram-negative and Gram-positive organisms.

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